CARBAMYLATION, CHRONIC INFLAMMATORY STATUS, AND OXIDATIVE STRESS IN CHRONIC RENAL DISEASE: Promoting Factors of Carcinogenesis
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ABSTRACT
Currently, cancer is the second most deadly disease in the world. For this reason, it has been the target of numerous studies, among them, some suggest the relationship with chronic kidney disease. It is known that cancer is a multifactorial disease, and recent studies support oxidative stress as a precursor to carcinogenesis, promoting ADN damage, activating oncogenes and inactivating tumor suppressor genes such as p53. This study is a descriptive bibliographical review that aimed to evidence the carcinogenesis related to chronic kidney disease. Through this study, it was possible to understand that chronic kidney patients are more prone to carcinogenesis related to metabolic and inflammatory disorders that culminate with oxidative stress. This paper presents the main carcinogenic pathways described in the literature related to CKD.
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